Zóna pre zamestnancov
a študentov LF UK

Clinical Immunology

Syllabus of lectures

Syllabus of lectures on Clinical Immunology, Academic year 2017/2018, Winter term


1.) 6.10.2017. Autoimmunity.

J. Javor, MD., PhD.

Immunological tolerance. Genetic predisposition to the development of autoimmune processes. Pathogenic mechanisms of autoimmune processes, the role of autoantigens. Hormones and environmental factors in the induction of autoimmune processes. Autoinflammatory diseases.


2.) 13.10.2017. Selected autoimmune disorders, I.

prof. M. Buc, MD., DrSc.

Immunopathogenesis of selected autoimmune diseases (type 1 diabetes mellitus, Crohn´s disease, ulcerative colitis, celiac disease).


3.) 20.10.2017. Selected autoimmune disorders, II. (!! The lecture will not be held on 20.10., replacement term to be determined soon !!!)

J. Javor, MD., PhD.

Immunopathogenesis of selected autoimmune diseases (myasthenia gravis, multiple sclerosis, psoriasis vulgaris, rheumatoid arthritis).


4.) 27.10.2017. Hypersensitive reactions – type I. Allergies.

assoc. prof. M. Bucová, MD., PhD.

Atopy and anaphylaxis. Immunopathogenetic mechanisms of type I HSR. Allergens, IgE antibodies, Fc-receptors, mast cells and basophils, primary and secondary mediators of allergic reactions. Genetics of allergy. Anaphylactic shock. Therapy of anaphylactic shock. Pseudoallergic reactions - non-IgE mediated allergic reactions.


5.) 3.11.2017. Hypersensitivity reactions - types II - V.

assoc. prof. M. Bucová, MD., PhD.

Immunopathogenetic mechanisms and clinical symptomatology. Complement and K cell-mediates cytotoxic reactions. Immune complex-mediated hypersensitivity reactions. Delayed type of hypersensitivities. Antibody-dependent stimulatory and inhibitory hypersensitivity reactions. Serum disease vs. serum shock.


6.) 10.11.2017. Transplantation of tissues and organs.

assoc. prof. I. Shawkatova, Mgr., PhD.  

Nomenclature of transplantations. Transplantation reactions HvG and GvH. Exception from rejections. Kidney and bone marrow transplantations.


7.) 17.11.2017. Inflammation. Sepsis.

assoc. prof. M. Bucová, MD., PhD.

Systemic inflammation, MODS, MOF and septic shock. Laboratory diagnosis of systemic inflammation – the role of procalcitonin, CRP, neopterin HMGB1, TREM-1. Differential diagnosis of systemic inflammation.


8.) 24.11.2017. Immunodeficiences. AIDS.

assoc. prof. M. Bucová, MD., PhD.

Hallmarks of immunodeficiences, occurrence rates, nomenclature of AIDS. Structure of HIV. Interactions between HIV and target cells. Clinical stages of AIDS. Diagnosis and therapy. Epidemiology of HIV infections and prevention. Overview of primary and secondary immunodeficiencies.


9.) 1.12.2017. Manipulation of immune mechanisms, I.

prof. M. Buc, MD., DrSc.

Immunoprevention, immunoprofylaxis. Types of vaccines, vaccination program in Slovakia. Immunostimulatory and immunosuppresive drugs.


10.) 8.12.2017. Manipulation of immune mechanisms, II.

prof. M. Buc, MD., DrSc.

Monoclonal antibodies and cytokines in the therapy of autoimmune diseases, infections and tumours. Gene therapy. Therapy by peptides, fusion proteins and small molecules.


11.) 15.12.2017. Tumours and immune system.

assoc. prof. V. Ďurmanová, RNDr., PhD.

Etiology of malignant transformations of cells (the role of physical, chemical and biological factors). Immunological surveillance. Escape mechanisms of tumour cells from immunological surveillance. Metastatic processes. Immunodiagnosis and immunotherapy.


12.) 22.12.2017. Immunology of gravidity. Fetomaternal interactions.

assoc. prof. V. Ďurmanová, RNDr., PhD.

Immunological paradox in gravidity. Tolerance of the fetus by the immune system of the mother. The role of HLA-G. Immune system development in fetus and newborns.



assoc. prof. Mária Bucová, MD., PhD.

Head of the department

Bratislava, September 9, 2017


Lectures will be held in the room M112 on Moskovská street N. 2 on Fridays between 4.30 p.m. and 6.20 p.m.

Study literature

Obligatory textbook                                                  

Buc M:  Basic and Clinical Immunology. Bratislava: Comenius University 2011, 305 p.


Recommended textbooks 

Abbas AK, Lichtman, AH, Pillai S: Cellular and molecular immunology. 6th ed. New York: WB Saunders Comp. 2007, 566 s

Murphy K, Travers P, Walport M: Janeway´s Immunobiology. 7th ed. New York: Garland Science, Taylor & Francis Group, LLC 2008, 887 p.

Kindt TJ et al.: Kuby´s Immunology. 6th ed. New York: W. H. Freeman Comp. 2007, 574 p.

Delves PJ, Martin SJ, Burton DR, Roitt I: Roitt´s Essential Immunology. 11th ed. London: Blackwell Publishing Limited 2006, 496