Clinical Immunology
Syllabus of lectures
Syllabus of lectures on Clinical Immunology, Academic year 2019/2020, Winter term
1.) 27.9.2019. Autoimmunity.
Prof. Milan Buc, MD., DSc.
Immunological tolerance. Genetic predisposition to the development of autoimmune processes. Pathogenic mechanisms of autoimmune processes, the role of antigen. Hormones and environmental factors in the induction of autoimmune processes. Autoinflammatory diseases.
2.) 11.10.2019. Selected autoimmune disorders, I.
Prof. Milan Buc, MD., DSc.
Immunopathogenesis of selected autoimmune diseases (type 1 diabetes mellitus, Crohn´s disease, ulcerative colitis, multiple sclerosis, neuromyelitis optica).
3.) 18.10.2019. Selected autoimmune disorders, II
Juraj Javor, MD., PhD.
Immunopathogenesis of selected autoimmune diseases (myasthenia gravis, psoriasis vulgaris, rheumatoid arthritis, systemic lupus erythematosus).
4.) 25.10.2019. Hypersensitive reactions – type I. Allergies.
Assoc. prof. Mária Bucová, MD., PhD.
Atopy and anaphylaxis. Immunopathogenetic mechanisms of type I HSR. Allergens, IgE antibodies, Fc-receptors, mast cells, basophils and eosinophils. Primary and secondary mediators of allergic reactions. Genetics of allergy. Anaphylactic shock. Therapy of anaphylactic shock. Pseudoallergic reactions - non-IgE mediated allergic reactions.
5.) 1.11.2019. Hypersensitivity reactions - types II - V.
Assoc. prof. Mária Bucová, MD., PhD.
Immunopathogenetic mechanisms and clinical symptomatology. Complement and K cell-mediates cytotoxic reactions. Immune complex-mediated hypersensitivity reactions. Delayed type of hypersensitivities. Antibody-dependent stimulatory and inhibitory hypersensitivity reactions. Serum disease vs. serum shock.
6.) 8.11.2019. Inflammation. Sepsis and septic shock.
Assoc. prof. Mária Bucová, MD., PhD.
Systemic inflammation, MODS, MOF and septic shock. The role of Th1 and Th2 immunity and pro- and anti-inflammatory immune response. SIRS, CARS, MARS. The role of HPA axis. Laboratory diagnosis of systemic inflammation – Neu/Ly ratio, procalcitonin, CRP, neopterin, HMGB1, TREM-1. Differential diagnosis of systemic infectious vs. non-infectious inflammation.
7.) 15.11.2019. Manipulation of immune mechanisms, I.
Prof. Milan Buc, MD., DSc.
Immunoprevention, immunoprofylaxis. Types of vaccines, vaccination program in Slovakia. Immunostimulatory and immunosuppresive drugs.
8.) 22.11.2019. Manipulation of immune mechanisms, II.
Prof. Milan Buc, MD., DSc.
Monoclonal antibodies and cytokines in the therapy of autoimmune diseases, infections and tumours. Gene therapy. Therapy by peptides, fusion proteins and small molecules.
9.) 29.11.2019. Immunology of pregnancy. Fetomaternal interactions.
Assoc. prof. Vladimíra Ďurmanová, MSc., PhD.
Immunological paradox in pregnancy. Tolerance of the fetus by the immune system of the mother. The role of HLA-G. Immune system development in fetus and newborns.
10.) 6.12.2019. Transplantation of tissues and organs.
Assoc. prof. Ivana Shawkatová, MSc., PhD.
Nomenclature of transplantations. Transplantation reactions HvG and GvH. Exception from rejections. Kidney and bone marrow transplantations.
11.) 13.12.2019. Tumours and immune system.
Assoc. prof. Vladimíra Ďurmanová, MSc., PhD.
Etiology of malignant transformations of cells (the role of physical, chemical and biological factors). Immunological surveillance, hallmarks of cancer. Antitumour immunity. Role of inflammation. Escape mechanisms of tumour cells from immunological surveillance. Metastatic processes. Immunodiagnosis and immunotherapy.
12.) 20.11.2019. Immunodeficiencies. AIDS.
Assoc. prof. Mária Bucová, MD., PhD.
Hallmarks of immunodeficiencies. Overview of primary and secondary immunodeficiencies. Occurrence rates, nomenclature of AIDS. Structure of HIV. Interactions between HIV and target cells. Clinical stages of AIDS. Epidemiology of HIV infections and prevention. Diagnosis and therapy.
Assoc. prof. Mária Bucová, MD., PhD.
Head of the department
Bratislava, September 4, 2019
Lectures will be held in the room M112 on Moskovská street N. 2 on Fridays between 4.30 p.m. and 6.20 p.m.
Study literature
Obligatory textbook
Buc M: Basic and Clinical Immunology. Bratislava: Comenius University 2011, 305 p.
Recommended textbooks
Abbas AK, Lichtman, AH, Pillai S: Cellular and molecular immunology. 6th ed. New York: WB Saunders Comp. 2007, 566 s
Murphy K, Travers P, Walport M: Janeway´s Immunobiology. 7th ed. New York: Garland Science, Taylor & Francis Group, LLC 2008, 887 p.
Kindt TJ et al.: Kuby´s Immunology. 6th ed. New York: W. H. Freeman Comp. 2007, 574 p.
Delves PJ, Martin SJ, Burton DR, Roitt I: Roitt´s Essential Immunology. 11th ed. London: Blackwell Publishing Limited 2006, 496