Clinical Biochemistry
Responsible teacher: assoc. prof. RNDr. Eva Uhlíková, PhD.
Contact person: eva.uhlikova@fmed.uniba.sk
Test structure for the Clinical biochemistry exam
The 1st part of the test consist of 32 multiple-choice test questions with 4 possible answers. Maximum number of points for the 1st part of the test is 128 points.
The 2nd part of the test consist of 8 open questions:
- 2 questions are an analysis of a patient with disorder of acid-base balance. Each is evaluated with 6 points.
- 2 questions are the choice of a suitable laboratory examination for a certain diagnosis. Each is evaluated with 4 points.
- 2 questions are calculations, e.g. creatinine clearance, fractional excretion, LDL-cholesterol. A correct answer is evaluated with 3 points.
- 1 question is an analysis of a patient with endocrine system dysfunction. A correct answer is evaluated with 4 points.
- 1 question is from reference values. A correct answer is evaluated with 2 points.
The maximum number of points for the 2nd part of the test is 32 points.
The minimum number of points required to pass the test is 121 (75%).
Exam from Clinical Biochemistry_2023-2024
Reference values required for the test
parameter | values | parameter | values |
Hemoglobin | 135-175 g/L M 115-160 g/L F | Albumin | 35-53 g/L |
Hematocrit | 39-51% M 33-42% F | Urea in serum | 2.5-8.3 mmol/L |
Erythrocytes | 4.2-5.7x1012/L M 3.5-5.1x1012/L F | Uric acid | 140-420 µmol/L |
Leukocytes | 4.1-10.2x109/L | Creatinine | 40-110 µmol/L |
Thrombocytes | 150-400x109/L | Total bilirubin | to 20 µmol/L |
Total proteins | 60-80 g/L | Conjugated bilirubin | to 5 µmol/L |
Sodium | 132-145 mmol/L | Triglycerides | 0.7-1.9 mmol/L |
Potassium | 3.8-5.2 mmol/L | Total cholesterol | 3.8-5.2 mmol/L |
Chlorides | 97-108 mmol/L | HDL-cholesterol | F ˃ 1.6 mmol/L M ˃ 1.4 mmol/L |
Calcium | 2.25-2.75 mmol/L | LDL-cholesterol | < 3.4 mmol/L |
Glycemia | 3.3-5.6 mmol/L | Glycated hemoglobin | < 4 mmol/L |
Iron | 14.3-26.0 µmol/L M 10.7-21.5 µmol/L F | Serum phosphates | 0.7-1.6 mmol/L |
Program of lectures
Programme of the subject: CLINICAL BIOCHEMISTRY Study branch: GENERAL MEDICINE – 4th year Medical faculty UK L E C T U R E S Winter semester – academic year 2023/2024 |
Date | Topic of the lecture | Lecturer |
1. | General clinical biochemistry – instruction, laboratory examination and its phases, pre-analytic, analytic and post-analytic phase. Diagnostic criteria of laboratory test. Reference values and evaluation of laboratory tests results. | doc. Uhlíková |
2. | Plasma proteins in diagnostics. Hyper- and hypoproteinaemia. Monoclonal gammopathies and their diagnosis. | doc. Uhlíková |
3. | Fundamentals of clinical enzymology. Examination of enzyme activities in diagnostics. | doc. Uhlíková |
4. | Lipid parameters in diagnostics. Hyperlipoproteinemia’s and their classification. Diagnosis of lipid metabolism disorders. | doc. Uhlíková |
5. | Laboratory tests in diabetology. Diagnosis and monitoring of a patient with diabetes mellitus. Diabetic complications. | doc. Uhlíková |
6. | Laboratory tests in gastroenterology. Gastric examination, examination of pancreatic function and small intestine resorption disorders. | doc. Uhlíková |
7. | Laboratory tests in hepatology. Examination of liver disorders and hepatic function. Cholestasis and its diagnosis. | doc. Uhlíková |
8. | Laboratory tests in nephrology. Urine examination – physical, chemical and microscopic. Examination of glomerular filtration and tubular function. | doc. Uhlíková |
9. | Laboratory tests in cardiology. Myocardial ischemia and diagnostics of acute myocardial infarction. Risk factors of atherosclerosis. | doc. Uhlíková |
10. | Laboratory tests in cancer patients. Tumour markers and their use in the diagnosis and monitoring of patients with oncological diseases. | doc. Uhlíková |
11. | Laboratory tests for some endocrinological diseases. Examination of thyroid function and function of adrenal cortex. | doc. Uhlíková |
12. | Acid-base balance disorders and their diagnostics. Acidosis, alkalosis and combined acid-base balance disorders. | doc. Uhlíková |
13. | Investigation of less common biological fluids – cerebrospinal fluid, synovial fluid and amniotic fluid. | doc. Uhlíková |