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Clinical Biochemistry

Responsible teacher: assoc. prof. RNDr. Eva Uhlíková, PhD.

Contact person: eva.uhlikova@fmed.uniba.sk
 

Announcement

Lectures from Clinical Biochemistry will be online in recorded form and will be published sequentially in MS TEAMS in a team available for all 4th year students. Students who will transfer the Clinical Biochemistry subject can apply to join this team at: lucia.laubertovafmed.uniba.sk
 

Exam from Clinical Biochemistry_2022-2023

Test structure for exam from Clinical Biochemistry

The test consists of 40 questions, 32 questions of which are of multiple-choice character. These questions can have 1,2,3,4 or none correct answers. For completely correctly answered question, the student gets 4 points, which results in 128 maximum achievable points.

The remaining 8 questions are open questions: 

  • Two questions are the cases of a patient with an acid-base balance disorder, in which pH, pCO2 and HCO3 values are some other laboratory data are provided, and the task is to write down what type of disorder the patient has (each of these 2 questions are for 6 points if completely correctly answered).
  • One question is calculation of lipoprotein parameter (completely correct answer = 2 points)
  • One question is calculation of creatinine clearance and reabsorption of water (completely correct answer = 4 points)
  • Two questions are to suggest a suitable diagnostic test for a certain diagnosis or for which diagnosis a certain test is used (each of these 2 questions are for 4 points if completely correctly answered))
  • In one question it is necessary to write reference values for a certain laboratory parameter (completely correct answer = 2 points).
  • One question is to diagnose the type of endocrine disorder based on the given laboratory parameters (completely correct = 4points).
     

As some questions have calculation character, student has to bring calculator because the cell phones, tablets, or other devices are not allowed. Maximum achievable points from these 8 open questions is 32.

Totally 160 points can be obtained from whole test. A minimum of 129 points (more than 80 %) is required to pass the exam. The time to complete the test is 60 minutes.

Students should wait in front of the Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry (Sasinkova 2, 2nd floor) 5 minutes before the beginning of the test.
 

Reference values required for the test

parameter

values

parameter

values

Hemoglobin

135-175 g/L    M

115-160 g/L    F

Albumin

35-53 g/L

Hematocrit

39-51%   M

33-42%   F

Urea in serum

2.5-8.3 mmol/L

Erythrocytes

4.2-5.7x1012/L   M

3.5-5.1x1012/L   F

Uric acid

140-420 µmol/L

Leukocytes

4.1-10.2x109/L

Creatinine

40-110 µmol/L

Thrombocytes

150-400x109/L

Total bilirubin

to 20 µmol/L

Total proteins

60-80 g/L

Conjugated bilirubin

to 5 µmol/L

Sodium

132-145 mmol/L

Triglycerides

0.7-1.9 mmol/L

Potassium

3.8-5.2 mmol/L

Total cholesterol

3.8-5.2 mmol/L

Chlorides

97-108 mmol/L

HDL-cholesterol

F    ˃  1.6 mmol/L

M   ˃ 1.4 mmol/L

Calcium

2.25-2.75 mmol/L

LDL-cholesterol

<  3.4 mmol/L

Glycemia

3.3-5.6 mmol/L

Glycated hemoglobin

< 4 mmol/L

Iron

14.3-26.0 µmol/L   M

10.7-21.5 µmol/L   F

Serum phosphates

0.7-1.6 mmol/L

Program of lectures

Programme of the subject: CLINICAL BIOCHEMISTRY

Study branch: GENERAL MEDICINE – 4th year Medical faculty UK

L E C T U R E S

Winter semester – academic year 2022/2023

 

 

Date

Topic of the lecture

Lecturer

1.

General clinical biochemistry – instruction, laboratory examination and its phases, pre-analytic, analytic and post-analytic phase. Diagnostic criteria of laboratory test. Reference values and evaluation of laboratory tests results.

doc. Uhlíková

2.

Plasma proteins in diagnostics. Hyper- and hypoproteinaemia. Monoclonal gammopathies and their diagnosis.

doc. Uhlíková

3.

Fundamentals of clinical enzymology. Examination of enzyme activities in diagnostics.

doc. Uhlíková

4.

Lipid parameters in diagnostics. Hyperlipoproteinemia’s and their classification. Diagnosis of lipid metabolism disorders.

doc. Uhlíková

5.

Laboratory tests in diabetology. Diagnosis and monitoring of a patient with diabetes mellitus. Diabetic complications.

doc. Uhlíková

6.

Laboratory tests in gastroenterology. Gastric examination, examination of pancreatic function and small intestine resorption disorders.

doc. Uhlíková

7.

Laboratory tests in hepatology. Examination of liver disorders and hepatic function. Cholestasis and its diagnosis.

doc. Uhlíková

8.

Laboratory tests in nephrology. Urine examination – physical, chemical and microscopic. Examination of glomerular filtration and tubular function.

doc. Uhlíková

9.

Laboratory tests in cardiology. Myocardial ischemia and diagnostics of acute myocardial infarction. Risk factors of atherosclerosis.

doc. Uhlíková

10.

Laboratory tests in cancer patients. Tumour markers and their use in the diagnosis and monitoring of patients with oncological diseases.

doc. Uhlíková

11.

Laboratory tests for some endocrinological diseases. Examination of thyroid function and function of adrenal cortex.

doc. Uhlíková

12.

Acid-base balance disorders and their diagnostics. Acidosis, alkalosis and combined acid-base balance disorders.

doc. Uhlíková

13.

Investigation of less common biological fluids – cerebrospinal fluid, synovial fluid and amniotic fluid.

doc. Uhlíková