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Clinical Biochemistry

Responsible teacher: assoc. prof. RNDr. Eva Uhlíková, PhD.

Contact person: eva.uhlikova@fmed.uniba.sk

Program of lectures

Programme of the subject: CLINICAL BIOCHEMISTRY

Study branch: GENERAL MEDICINE – 4th year Medical faculty UK

L E C T U R E S

Winter semester – academic year 2020/2022

 

 

Date

Topic of the lecture

Lecturer

1.

General clinical biochemistry – instruction, laboratory examination and its phases, pre-analytic, analytic and post-analytic phase. Diagnostic criteria of laboratory test. Reference values and evaluation of laboratory tests results.

doc. Uhlíková

2.

Plasma proteins in diagnostics. Hyper- and hypoproteinaemia. Monoclonal gammopathies and their diagnosis.

doc. Uhlíková

3.

Fundamentals of clinical enzymology. Examination of enzyme activities in diagnostics.

doc. Uhlíková

4.

Lipid parameters in diagnostics. Hyperlipoproteinemia’s and their classification. Diagnosis of lipid metabolism disorders.

doc. Uhlíková

5.

Laboratory tests in diabetology. Diagnosis and monitoring of a patient with diabetes mellitus. Diabetic complications.

doc. Uhlíková

6.

Laboratory tests in gastroenterology. Gastric examination, examination of pancreatic function and small intestine resorption disorders.

doc. Uhlíková

7.

Laboratory tests in hepatology. Examination of liver disorders and hepatic function. Cholestasis and its diagnosis.

doc. Uhlíková

8.

Laboratory tests in nephrology. Urine examination – physical, chemical and microscopic. Examination of glomerular filtration and tubular function.

doc. Uhlíková

9.

Laboratory tests in cardiology. Myocardial ischemia and diagnostics of acute myocardial infarction. Risk factors of atherosclerosis.

doc. Uhlíková

10.

Laboratory tests in cancer patients. Tumour markers and their use in the diagnosis and monitoring of patients with oncological diseases.

doc. Uhlíková

11.

Laboratory tests for some endocrinological diseases. Examination of thyroid function and function of adrenal cortex.

doc. Uhlíková

12.

Acid-base balance disorders and their diagnostics. Acidosis, alkalosis and combined acid-base balance disorders.

doc. Uhlíková

13.

Investigation of less common biological fluids – cerebrospinal fluid, synovial fluid and amniotic fluid.

doc. Uhlíková

Reference values required for the test

parameter

values

parameter

values

Hemoglobin

135-175 g/L    M

115-160 g/L    F

Albumin

35-53 g/L

Hematocrit

39-51%   M

33-42%   F

Urea in serum

2.5-8.3 mmol/L

Erythrocytes

4.2-5.7x1012/L   M

3.5-5.1x1012/L   F

Uric acid

140-420 µmol/L

Leukocytes

4.1-10.2x109/L

Creatinine

40-110 µmol/L

Thrombocytes

150-400x109/L

Total bilirubin

to 20 µmol/L

Total proteins

60-80 g/L

Conjugated bilirubin

to 5 µmol/L

Sodium

132-145 mmol/L

Triglycerides

0.7-1.9 mmol/L

Potassium

3.8-5.2 mmol/L

Total cholesterol

3.8-5.2 mmol/L

Chlorides

97-108 mmol/L

HDL-cholesterol

F    ˃  1.6 mmol/L

M   ˃ 1.4 mmol/L

Calcium

2.25-2.75 mmol/L

LDL-cholesterol

<  3.4 mmol/L

Glycemia

3.3-5.6 mmol/L

Glycated hemoglobin

< 4 mmol/L

Iron

14.3-26.0 µmol/L   M

10.7-21.5 µmol/L   F

Serum phosphates

0.7-1.6 mmol/L